Publications

  1. RNase H-sensitive multifunctional ASO-based constructs as promising tools for the treatment of multifactorial complex pathologies

Mata-Ventosa, A. Vila-Planas, A. Solsona-Pujol, J. de la Dueña, M. Torrents, E. Izquierdo-García, M. Pastor-Anglada, S. Pérez-Torras,* M. Terrazas* (*Corresponding)

Bioorg. Chem. 2024, 150, 107595 | DOI: 10.1016/j.bioorg.2024.107595

  1. Site-specific incorporation of a fluorescent nucleobase analog enhances i-motif stability and allows monitoring of i-motif folding inside cells

B. Mir, I. Serrano-Chacón, P. Medina, V. Macaluso, M. Terrazas, A. Gandioso, M. Garavís, M. Orozco, N. Escaja, C. González

Nucleic Acids Res. 2024, 52, 5575–3389 | DOI: 10.1093/nar/gkae106

  1. Systematic study of hybrid triplex topology and stability suggests a general triplex-mediated regulatory mechanism

Genna, G. Portella, A. Sala, M. Terrazas, N. Villegas, L. Mateo, C. Castellazzi, M. Labrador, A. Aviñó, A. Hospital, A. Grandioso, P. Aloy, I. Brun-Heath, C. Gonzalez, R. Eritja, M. Orozco

bioRxiv 2024 | DOI: 10.1101/2024.05.28.596189

  1. Special issue “Frontiers in nucleic acid chemistry—in memory of Professor Enrique Pedroso for his outstanding contributions to nucleic acid chemistry

Eritja,* D. Montesarchio,* M. Terrazas* (Co-corresponding)

Molecules 2023, 28 (21), 7278 | DOI: 10.3390/molecules28217278

  1. Controlled sulfur-based engineering confers mouldability to phosphorothioate antisense oligonucleotides

Genna, J. Iglesias-Fernández, L. Reyes-Fraile, N. Villegas, K. Guckian, P. Seth, B. Wan, C. Cabrero, M. Terrazas, I. Brun-Heath, C. González, S. Sciabola, A. Villalobos, M. Orozco

Nucleic Acids Res. 2023, 51, 4713–4725 | DOI: 10.1093/nar/gkad309

  1. Mechanism of reaction of RNA-dependent RNA polymerase from SARS-CoV-2

Juan Aranda, Milosz Wieczór, Montserrat Terrazas, Isabelle Brun-Heath, Modesto Orozco

Chem Catal. 2023, 2, 1084–1099 | DOI: 10.1016/j.checat.2022.03.019

  1. Molecular basis of Arginine and Lysine DNA sequence-dependent thermo-stability modulation

Martin, P.D. Dans, M. Wieczór, N. Villegas, I. Brun-Heath, F. Battistini, M. Terrazas, M. Orozco

PLoS Comput. Biol. 2022, 18, e1009749 | DOI: 10.1371/journal.pcbi.1009749

  1. The impact of the hydroxymethylcytosine epigenetic signature on DNA structure and function

Battistini, P.D. Dans, M. Terrazas, C.L. Castellazzi, G. Portella, M. Labrador, N. Villegas, I. Brun-Heath, C. González, M. Orozco

PLoS Comput. Biol. 2021, 17, e1009547 | DOI: 10.1371/journal.pcbi.1009547

  1. Dynamics-Function Analysis in Catalytic RNA Using NMR Spin Relaxation and Conformationally Restricted Nucleotides

C.G. Hoogstraten, M. Terrazas, A. Aviñó, N.A. White, M. Sumita

In: Scarborough, R.J., Gatignol, A. (eds) Ribozymes. Methods in Molecular Biology, 2021, vol 2167. Humana, New York, NY. | DOI: 10.1007/978-1-0716-0716-9_11

  1. The origins and the biological consequences of the Pur/Pyr DNA· RNA asymmetry

Terrazas, V. Genna, G. Portella, N. Villegas, D. Sanchez, C. Arnan, C. Pulido-Quetglas, R. Johnson, R. Guigó, I. Brun-Heath, A. Aviñó, R. Eritja, M. Orozco

CHEM 2019, 5, 1619–1631 | DOI: 10.1016/j.chempr.2019.04.002

  1. An artificial DNAzyme RNA ligase shows a reaction mechanism resembling that of cellular polymerases

Aranda, M. Terrazas, H. Gomez, N. Villegas, M. Orozco

Nat. Catal. 2019, 2, 544–552 | DOI: 10.1038/s41929-019-0290-y

  1. A multifunctional toolkit for target-directed cancer therapy

Terrazas,* D. Sánchez, F. Battistini, N. Villegas, I. Brun-Heath, M. Orozco (*Corresponding)

Chem. Commun. 2019, 55, 802–805 | DOI: 10.1039/C8CC08823C

  1. Efficient siRNA–peptide conjugation for specific targeted delivery into tumor cells

Gandioso, A. Massaguer, N. Villegas, C. Salvans, D. Sánchez, I. Brun-Heath, V. Marchán,* M. Orozco, M. Terrazas* (*Corresponding)

Chem. Commun. 2017, 53, 2870–2873 | DOI: 10.1039/C6CC10287E

  1. Rational design of novel N-alkyl-N capped biostable RNA nanostructures for efficient long-term inhibition of gene expression

Terrazas,* I. Ivani, N. Villegas, C. Paris, C. Salvans, I. Brun-Heath, M. Orozco (* Corresponding)

Nucleic Acids Res. 2016, 44, 4354–4367 | DOI: 10.1093/nar/gkw169

  1. Can A denaturant stabilize DNA? Pyridine reverses DNA denaturation in acidic pH

Portella,† M. Terrazas,† N. Villegas, C. González, M. Orozco (†Shared first authoship)

Angew. Chem. Int. Ed. 2015, 54, 10634–10637 | DOI: 10.1002/ange.201503770

  1. Modulation of the RNA interference activity using central mismatched siRNAs and acyclic threoninol nucleic acids (aTNA) units

Alagia, M. Terrazas, R. Eritja

Molecules 2015, 20, 7602–7619 | DOI: 10.3390/molecules20057602

  1. RNA/aTNA chimeras: RNAi effects and nucleases resistance of single and double stranded RNAs

A. Alagia, M. Terrazas, R. Eritja
Molecules 2014, 19, 17872–17896 | DOI: 10.3390/molecules191117872

  1. Challenges and opportunities for oligonucleotide-based therapeutics by antisense and RNA interference mechanisms

R. Eritja, M. Terrazas, S. Grijalvo, A. Aviñó, A. Alagia, S. Pérez-Rentero, J. Carlos Morales
In: Erdmann, V., Markiewicz, W., Barciszewski, J. (eds) Chemical Biology of Nucleic Acids. RNA Technologies. 2021, Springer, Berlin, Heidelberg. | DOI: 10.1007/978-3-642-54452-1_13

  1. Synthesis, RNAi activity and nulcease-resistant properties of apolar carbohydrates siRNA conjugates

Vengut-Climent, M. Terrazas, R. Lucas, M. Arévalo-Ruiz, R. Eritja, J. Carlos Morales
Bioorg. Med. Chem. Lett. 2013, 23, 4048–4051 | DOI: 10.1016/j.bmcl.2013.05.065

  1. Functionalization of the 3′-ends of DNA and RNA strands with N-ethyl-N-coupled nucleosides: A promising approach to avoid 3′-exonuclease-catalyzed hydrolysis of therapeutic oligonucleotides

Terrazas,* A. Alagia, I. Faustino, M. Orozco, R. Eritja* (*Co-corresponding)
ChemBioChem. 2013, 14, 510–520 | DOI: 10.1002/cbic.201200611

  1. Pd-catalysed amidation of 2, 6-dihalopurine nucleosides. Replacement of iodine at 0° C

Bosch, I. Cialîcu, J. Caner, X. Ariza, A.M. Costa, M. Terrazas, J. Vilarrasa
Tetrahedron Lett. 2012, 53, 1358–1362 | DOI: 10.1016/j.tetlet.2012.01.012

  1. Synthesis and properties of small interfering RNA duplexes carrying 5-ethyluridine residues

Terrazas, R. Eritja
Mol. Divers. 2011, 15, 677–686 | DOI: 10.1007/s11030-010-9290-1

  1. A direct, efficient method for the preparation of siRNAs containing ribo-like North bicyclo[3.1.0]hexane pseudosugars

Terrazas, A. Avino, M.A Siddiqui, V.E. Marquez, R. Eritja
Org. Lett. 2011, 13, 2888–2891 | DOI: 10.1021/ol200909j

  1. Effect of North bicyclo[3.1.0]hexane 2′‐deoxy‐pseudosugars on RNA Interference: A novel class of siRNA modification

Terrazas, S.M. Ocampo, J.C. Perales, V.E. Marquez, R. Eritja
ChemBioChem. 2011, 12, 1056–1065 | DOI: 10.1002/cbic.201000791 – Inside cover picture

  1. Synthesis of oligonucleotide–peptide conjugates for biomedical and technological applications

Synthesis of oligonucleotide–peptide conjugates for biomedical and technological applications
A. Aviñó, S. Grijalvo

  1. Synthesis and properties of oligonucleotides carrying isoquinoline imidazo[1,2-a]azine fluorescent units

Pérez-Rentero, N. Kielland, M. Terrazas, R. Lavilla, R. Eritja
Bioconj. Chem. 2010, 21, 1622–1628 | DOI: 10.1021/bc1000966

  1. Stepwise synthesis of oligonucleotide–peptide conjugates containing guanidinium and lipophilic groups in their 3′-termini

Grijalvo, M. Terrazas, A. Aviñó, R. Eritja
Bioorg. Med. Chem. Lett. 2010, 20, 2144–2147 | DOI: 10.1016/j.bmcl.2010.02.049

  1. Modified siRNAs for the study of the PAZ domain

Somoza, M. Terrazas, R. Eritja
Chem. Commun. 2010, 46, 4270–4272 | DOI: 10.1039/C003221B

  1. RNA major groove modifications improve siRNA stability and biological activity

Terrazas, E.T. Kool
Nucleic Acids Res. 2009, 37, 346–353 | DOI: 10.1093/nar/gkn958

  1. A multidisciplinary approach for the identification of novel HIV‐1 non‐nucleoside reverse transcriptase inhibitors: S‐DABOCs and DAVPs

Radi, C. Falciani, L. Contemori, E. Petricci, G. Maga, A. Samuele, S. Zanoli, M. Terrazas, M. Castria, A. Togninelli, J.A. Esté, I. Clotet‐Codina, M. Armand‐Ugón, M. Botta

ChemMedChem 2008, 3, 573–593 | DOI: 10.1002/cmdc.200700198

  1. Enzymatically catalyzed DNA synthesis using L‐Asp‐dGMP, L‐Asp‐dCMP, and L‐Asp‐dTMP

Terrazas, P. Marlière, P. Herdewijn
Chem. & Biodivers. 2008, 5, 31–39 | DOI: 10.1002/cbdv.200890013

  1. Enzymatically catalyzed DNA synthesis using L‐Asp‐dGMP, L‐Asp‐dCMP, and L‐Asp‐dTMP

Terrazas, P. Marlière, P. Herdewijn
In: Piet Herdewijn, M. Volkan Kısakürek (eds.), Origin of Life. Chemical approach, 2008, Wiley-VCH Verlag GmbH & Co. KGaA, p. 363–371

  1. Polymerase-catalyzed synthesis of DNA from phosphoramidate conjugates of deoxynucleotides and amino acids

O. Adelfinskaya, M. Terrazas, M. Froeyen, P. Marliere, K. Nauwelaerts, P. Herdewijn
Nucleic Acids Res. 2007, 35, 5060–5072 | DOI: 10.1093/nar/gkm498

  1. Discovery of non-nucleoside inhibitors of HIV-1 reverse transcriptase competing with the nucleotide substrate

G. Maga, M. Radi, S. Zanoli, F. Manetti, R. Cancio, U. Hübscher, S. Spadari, C. Falciani, M. Terrazas, J. Vilarrasa, M. Botta
Angew. Chem. Int. Ed. 2007, 46, 1810–1813 | DOI: 10.1002/anie.200604165

  1. Advantages of the Ns group in the reactions of N1-SO2R inosines with benzylamine and with 15NH3

M. Terrazas, X. Ariza, J. Vilarrasa
Tetrahedron Lett. 2005, 31, 5127–5130 | DOI: 10.1016/j.tetlet.2005.05.137

  1. [N,1-15N2]-2‘-Deoxyadenosines

M. Terrazas, X. Ariza, J. Vilarrasa
Org. Lett. 2005, 7, 2477–2479 | DOI: 10.1021/ol050788w

  1. A novel nucleophilic approach to 1-alkyladenosines. A two-step synthesis of [1-15N] adenosine from inosine

M. Terrazas, X. Ariza, J. Farràs, J. Vilarrasa
Chem. Commun. 2005, 31, 3968–3970 | DOI: 10.1039/B505183E

  1. A direct, efficient method for the preparation of N6-protected 15N-labeled adenosines

M. Terrazas, X. Ariza, J. Farràs, J.M. Guisado-Yang, J. Vilarrasa
J. Org. Chem. 2004, 69, 5473–5475 | DOI: 10.1021/jo049490u